Once global standardized classification and subsequent stratification validates the proposed up\ and downstream subclasses, multicenter tests using targeted therapies adjunctive to established guide\directed medical therapy could be initiated to prove their incremental worth

Once global standardized classification and subsequent stratification validates the proposed up\ and downstream subclasses, multicenter tests using targeted therapies adjunctive to established guide\directed medical therapy could be initiated to prove their incremental worth. or arrest disease development possibly. Desk 1