Given the multifactorial nature of the human B cell malignancies, these animal models present their individual suitability to different study designs and to investigate not only the biology of human B cell malignancies but also to evaluate in vivo efficacy of new therapeutics

Given the multifactorial nature of the human B cell malignancies, these animal models present their individual suitability to different study designs and to investigate not only the biology of human B cell malignancies but also to evaluate in vivo efficacy

Dissected tissue was grown on 0

Dissected tissue was grown on 0.4?m Biopore filters (Millipore, UK) in 2.5?ml of serum-free culture medium (DMEM/Hams F12 1:1) containing 1 x ITS (insulin, transferrin and sodium selenite) (Sigma, UK), 0.025?mg/ml gentamicin (Sigma, UK), 0.06?mg/ml benzylpenicillin sodium, 0.1?mg/ml streptomycin sulphate