Two MMP13 inhibitors, WAY170523 and CL82198, significantly decreased promoter-driven luciferase activity with no an impact on cells transfected with pGL4.10. related amyloid- precursor proteins processing, amyloid- insert and eIF4B phosphorylation, whereas spatial and associative memory space and learning shows were
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N., and N. effect of HER2 on MLK3 kinase activity was mediated via its phosphorylation on Ser674 by AKT and that pharmacological inhibitors of PI3K/AKT prevented trastuzumab- and lapatinib-induced activation of MLK3 activity. Consistent with the pro-apoptotic function of MLK3,