SeeTable 4

SeeTable 4. Weighed against the control group, the CD4+ level and CD4+/CD8+ ratio in the HZ-control group had been decrease (P<0.05,P<0.01), and there is zero difference in the ratios of Compact disc3+, Compact disc19+, Compact disc8+, and Compact disc56+. in immune system features and their romantic relationship with PHN. == Outcomes == Weighed against the control group, the degrees of Compact disc3+ and Compact disc4+ and Compact disc4+/Compact disc8+ ratios of HZ sufferers were considerably lower (P<0.05). Among 188 HZ sufferers, (24S)-24,25-Dihydroxyvitamin D3 91 (48.4%) developed PHN. The sufferers in the HZ-PHN group had been significantly old (P<0.01) as well as the levels of Compact disc3+, Compact disc4+, and Compact disc8+ and Compact disc4+/Compact disc8+ ratios were significantly less than those in the HZ-control group (P<0.05,P<0.01). Binary logistic regression evaluation showed that age group and Compact disc4+/Compact disc8+ ratios are indie risk elements for identifying whether HZ sufferers develop PHN. == Conclusions == Acute immunocompetent HZ sufferers, those who find themselves old and even more susceptible to developing PHN specifically, exhibit significant cellular immune dysregulation. Age and CD4+/CD8+ ratios may be useful predictors of PHN in acute HZ patients. Keywords:Herpes Zoster, Immunologic Tests, Neuralgia == Introduction == Varicella zoster virus (VZV) is transmitted through droplets or direct contact. The initial infection mainly causes chickenpox, and then VZV can ascend along sensory nerve axons or fuse with neurons through infected T cells, and transfer to the posterior root ganglia or cranial ganglia of the spinal cord. After the recovery from primary infection, VZV will lie dormant in the human body. When the hosts immune function is impaired, the VZV lurking in the ganglia can be activated, replicate, and transfer to the skin along sensory nerve fibers, resulting in typical unilateral aggregated blisters and pustules, known as herpes zoster (HZ) [2,3]. HZ can cause a series of complications, including postherpetic (24S)-24,25-Dihydroxyvitamin D3 neuralgia (PHN), keratitis, decreased vision, blindness, hearing impairment, facial paralysis, and central nervous system (CNS) infections. Among these, PHN is the most common complication [4]. The incidence and prevalence of HZ and PHN are significantly increasing [58]. Epidemiological data show that the prevalence of HZ in China is 7.7%, with 29.8% of HZ patients developing PHN [9]. Once PHN occurs, if not treated properly, the pain can persist for several years or even decades, causing huge suffering for patients. In severe cases, they may become unable to work or perform activities of daily living, causing heavy healthcare and economic burdens to families and society [10,11]. At present, there are many clinical methods for treating PHN, but the treatment effects are mostly unsatisfactory. However, early diagnosis and standardized treatment of HZ patients can significantly reduce the incidence of PHN [1214]. Therefore, early identification and intervention of PHN are extremely important. HZ is an immune-related disease, and PHN is closely related to the hosts (24S)-24,25-Dihydroxyvitamin D3 immune response. Immunocompromised HZ patients have a significantly increased probability of developing PHN [1517]. However, there are still many individuals with immunocompetent who undergo HZ and PHN in clinical practice. As an important component of the cellular immune system, lymphocyte subpopulations participate in various important immune responses in the body, exert immune functions, and participate in the occurrence of PHN [18,19]. Humoral immunity, which is an important component of the RBBP3 hosts immune system, plays a unique role and cooperates with cellular immunity to jointly exert immune responses. While the role of cellular immunity is established, it is unclear whether humoral immunity affects the incidence of PHN. The study of immune response in PHN is important for exploring its specific pathogenesis, early identification of PHN patients, and searching for potential therapeutic targets. Therefore, to provide reference for clinical physicians to identify, treat, and reduce the occurrence of PHN in the early stage, this study explored the roles of cellular and humoral immune functions in the occurrence and development of PHN in immunocompetent acute HZ patients. == Material and Methods == == Subjects == We enrolled 188 patients with acute HZ who were admitted in our hospital from April 2021 to June 2023 as the HZ group, and 79 individuals who underwent physical examinations at our hospital during the same period.