Knowing EpCAM signalling pathways might lead to a reassessment of EpCAM-based therapies. Keywords: epithelial cell adhesion molecule (EpCAM), lung carcinoma, proliferation, DNA microarray analysis, proliferation, cell cycle The epithelial cell adhesion molecule (EpCAM) was initially described as tumour-associated antigen (Koprowski studies demonstrated several possible mechanisms of action. an analysis of differentially indicated genes exposed the processes with the strongest over-representation of modulated genes, for example, cell cycle, cell death, cellular growth and proliferation, and malignancy. These data suggest that EpCAM is definitely involved in transmission transduction triggering several intracellular signalling pathways. Knowing EpCAM signalling pathways might lead to a reassessment of EpCAM-based therapies. Keywords: epithelial cell adhesion Thiostrepton molecule (EpCAM), lung carcinoma, proliferation, DNA microarray analysis, proliferation, cell cycle The epithelial cell adhesion molecule (EpCAM) was initially described as tumour-associated antigen (Koprowski studies demonstrated several possible mechanisms of action. Antitumoral effects have been ascribed to antibody- and complement-dependent cellular toxicity or anti-ideotypic immune response (Fagerberg untreated samples for upregulated genes, and a minimum intensity of 100 in control samples, a fold modify Rabbit Polyclonal to OR2T11 Acknowledgments We say thanks to Jessica D?ke for isolating the mouse lung carcinoma cell lines Thiostrepton and Ingrid Meder and Rong Lai for his or her excellent complex assistance. We also thank Micromed, Munich, Germany, who generously offered us with the anti-EpCAM antibody G8.8. The monetary support of Lower Saxony Ministry of Tradition and Technology to JB is definitely gratefully acknowledged. Footnotes Supplementary Info accompanies the paper on English Journal of Malignancy site (http://www.nature.com/bjc) Supplementary Material Supplementary Number S1Click here for additional Thiostrepton data file.(60K, ppt) Supplementary Furniture S1 and S2Click here for additional data file.(76K, doc) Supplementary Number LegendClick here for additional Thiostrepton data file.(20K, doc).

Knowing EpCAM signalling pathways might lead to a reassessment of EpCAM-based therapies