8480s), MMP9 (Cell Signaling Technology no

8480s), MMP9 (Cell Signaling Technology no.1366s). Hz, 1H, = 8.3, 2.3, 1.1 Hz, 1H, = 7.2 Hz, 2H, = 7.2 Hz, 3H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 6.1 Hz, 1H, = 7.1 Hz, 2H, = 7.9, 6.6 Hz, 9H, = 8.1 Hz, 1H, = 2.2 Hz, 1H, = 11.7, 8.4, 2.2, 0.9 Hz, 2H, = 6.0 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 8.1 Hz, 1H, = 8.5, 2.5, 0.9 Hz, 1H, = 7.8, 2.0, 0.9 Hz, 1H, = 2.2 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 8.7, 7.7 Hz, 1H, = 7.9, 2.2 Hz, 2H, = 1.9 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 8.1 Hz, 1H, = 2.2 Hz, 1H, = 0.8 Hz, 3H, = 0.8 Hz, 3H, = 2.2 Hz, 1H, = 7.9, 6.8, 2.0, 0.9 Hz, 2H, = 8.0, 2.3, 1.1 Hz, 1H, = 8.1, 2.2, 1.2 Hz, 2H, = 8.5 Hz, 2H, = 8.9 Hz, 2H, = 6.0 Hz, 1H, = 8.1 Hz, 1H, = PF-04957325 8.4, 2.5, 0.9 Hz, 1H, = 6.0 Hz, 1H, = 6.4 Hz, 2H, = 6.4 Hz, 3H, = 6.6 Hz, 2H, = 6.4 Hz, 3H, = 12.4, 8.1 Hz, 15H, = 8.3, 2.8 Hz, 2H, = 6.3 Hz, 2H, = 9.5 Hz, 3H, = 6.5 Hz, 2H, = 6.8 Hz, 3H, = 12.1 Hz, 9H, = 8.1 Hz, 1H, = 8.4, 2.6, 0.9 Hz, 1H, PF-04957325 = 7.2 Hz, 2H, = 6.6 Hz, 3H, = 6.6 Hz, 2H, = 10.5 Hz, 9H, = 8.1 Hz, 1H, = 8.0, 2.4, 1.2 Hz, 1H, = 6.3 Hz, 2H, = 5.4 Hz, 3H, = 6.6 Hz, 2H, = 9.5 Hz, 9H, = 8.3 Hz, 2H, = 6.4 Hz, 2H, = 6.3 Hz, 3H, = 6.5 Hz, 2H, = 7.0 Hz, 3H, = 11.3 Hz, 9H, = 9.1, 2.5 Hz, 2H, = 7.0 Hz, 2H, = 7.2 Hz, 2H, = 11.2 Hz, 9H, = 1.5 Hz, 3H, = 8.2 Hz, 1H, = 9.6 Hz, 1H, = 6.0 Hz, 1H, = 4.2 Hz, 3H, = 7.0 Hz, 2H, = 7.1 Hz, 2H, = 15.1 Hz, 9H, = 4.2 Hz, 3H, = 7.1 Hz, 2H, = 8.2 Hz, 1H, = 2.3 Hz, 1H, = 6.8, 2.8, 1.9, 0.9 Hz, 1H, = 7.1 Hz, 2H, = 7.2 Hz, 2H, = 8.0, 4.1, 2.0 Hz, 2H, = 7.3, 2.5, 1.2 Hz, 1H, = 7.1 Hz, 2H, = 7.4 Hz, 2H, = 5.5, 4.9 Hz, 1H, = 14.9, 6.8 Hz, 2H, = 4.9, 2.1 Hz, 3H, = 37.8 Hz, 3H, = 8.4, 7.4, 0.9 Hz, 1H, = 8.5, 2.3, 1.1 Hz, 1H, = 6.1 Hz, 1H, = 6.2, 1.3 Hz, 2H, = 6.4, 1.3 Hz, 2H, = 0.7 Hz, 3H, = 8.5, 2.5, 0.9 Hz, 1H, = 8.1, 1.5 Hz, 1H, = 4.2 Hz, 2H, = 3.9 Hz, 2H, = 6.4 Hz, 2H, = 6.4 Hz, 2H, = 1.2 Hz, 2H, = 6.1 Hz, 1H, = 8.1 Hz, 1H, = 8.5, 2.4, 0.9 Hz, 1H, = 8.5, 7.8 Hz, 1H, = 8.6, 2.5, 0.9 Hz, 1H, = 2.2 Hz, 1H, = 7.8, 2.1, 0.9 Hz, 1H, = 1.3 Hz, 2H, = 1.3 Hz, 3H, = 7.9, 2.0, 1.0 Hz, 1H, = 7.1 Hz, 2H, = PF-04957325 7.2 Hz, 3H, = 8.0 Hz, 1H, = 7.9, 2.1, 1.0 Hz, 1H, = 2.1 Hz, 1H, = 8.2, 2.4, 1.0 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.2 Hz, 2H, = 7.1 Hz, 3H, = 6.9, 2.3 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.5, 4.4 Hz, 4H, = 7.2 Hz, 3H, = 8.2 Hz, 1H, = 2.2 Hz, 1H, = 9.3, 8.4, 2.3, 1.0 Hz, 2H, = 8.8.Reagents and conditions: (a) STAB, DCE, RT; (b) HCl/EtOH, RT; (c) 1,3-bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea, Et3N, HgCl2, DMF, RT. Acknowledgments The authors thank Ian Paterson and Xinyi Yang for many helpful suggestions and corrections about the current manuscript. Abbreviations PRMT1Protein arginine methyltransferase 1SAMS-adenosyl-L-methioninemMAmonomethylarginineSAHS-adenosyl-L-homocysteineADMAAsymmetrical dimethylargineSDMASymmetrical dimethylarginineDIBAL-HDiisobutylaluminium hydrideSTABSodium triacetoxyborohydrideSARStructure-activity relationshipMOAMechanism of action Author Contributions W.H. 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 8.7, 7.7 Hz, 1H, = 7.9, 2.2 Hz, 2H, = 1.9 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 8.1 Hz, 1H, = 2.2 Hz, 1H, = 0.8 Hz, 3H, = 0.8 Hz, 3H, = 2.2 Hz, 1H, = 7.9, 6.8, 2.0, 0.9 Hz, 2H, = 8.0, 2.3, 1.1 Hz, 1H, = 8.1, 2.2, 1.2 Hz, 2H, = 8.5 Hz, 2H, = 8.9 Hz, 2H, = 6.0 Hz, 1H, = 8.1 Hz, 1H, = 8.4, 2.5, 0.9 Hz, 1H, = 6.0 Hz, 1H, = 6.4 Hz, 2H, = 6.4 Hz, 3H, = 6.6 Hz, 2H, = 6.4 Hz, 3H, = 12.4, 8.1 Hz, 15H, = 8.3, 2.8 Hz, 2H, = 6.3 Hz, 2H, = 9.5 Hz, 3H, = 6.5 Hz, 2H, = 6.8 Hz, 3H, = 12.1 Hz, 9H, = 8.1 Hz, 1H, = 8.4, 2.6, 0.9 Hz, 1H, = 7.2 Hz, 2H, = 6.6 Hz, 3H, = 6.6 Hz, 2H, = 10.5 Hz, 9H, = 8.1 Hz, 1H, = 8.0, 2.4, 1.2 Hz, 1H, = 6.3 Hz, 2H, = 5.4 Hz, 3H, = 6.6 Hz, 2H, = 9.5 Hz, 9H, = 8.3 Hz, 2H, = 6.4 Hz, 2H, = 6.3 Hz, 3H, = 6.5 Hz, 2H, = 7.0 Hz, 3H, = 11.3 Hz, 9H, = 9.1, 2.5 Hz, 2H, = 7.0 Hz, 2H, = 7.2 Hz, 2H, = 11.2 Hz, 9H, = 1.5 Hz, 3H, = 8.2 Hz, 1H, = 9.6 Hz, 1H, = 6.0 Hz, 1H, = 4.2 Hz, 3H, = 7.0 Hz, 2H, = 7.1 Hz, 2H, = 15.1 Hz, 9H, = 4.2 Hz, 3H, = 7.1 Hz, 2H, = 8.2 Hz, 1H, = 2.3 Hz, 1H, = 6.8, 2.8, 1.9, 0.9 Hz, 1H, = 7.1 Hz, 2H, = 7.2 Hz, 2H, = 8.0, 4.1, 2.0 Hz, 2H, = 7.3, 2.5, 1.2 Hz, 1H, = 7.1 Hz, 2H, = 7.4 Hz, 2H, = 5.5, 4.9 Hz, 1H, = 14.9, 6.8 Hz, 2H, = 4.9, 2.1 Hz, 3H, = 37.8 Hz, 3H, = 8.4, 7.4, 0.9 Hz, 1H, = 8.5, 2.3, 1.1 Hz, 1H, = 6.1 Hz, 1H, = 6.2, 1.3 Hz, 2H, = 6.4, 1.3 Hz, 2H, = 0.7 Hz, 3H, = 8.5, 2.5, 0.9 Hz, 1H, = 8.1, 1.5 Hz, 1H, = 4.2 Hz, 2H, = 3.9 Hz, 2H, = 6.4 Hz, 2H, = 6.4 Hz, 2H, = 1.2 Hz, 2H, = 6.1 Hz, 1H, = 8.1 Hz, 1H, = 8.5, 2.4, 0.9 Hz, 1H, = 8.5, 7.8 Hz, 1H, = 8.6, 2.5, 0.9 Hz, 1H, = 2.2 Hz, 1H, = 7.8, 2.1, 0.9 Hz, 1H, = 1.3 Hz, 2H, = 1.3 Hz, 3H, = 7.9, 2.0, 1.0 Hz, 1H, = 7.1 Hz, 2H, = 7.2 Hz, 3H, = 8.0 Hz, 1H, = 7.9, 2.1, 1.0 Hz, 1H, = 2.1 Hz, 1H, = 8.2, 2.4, 1.0 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.2 Hz, 2H, = 7.1 Hz, 3H, = 6.9, 2.3 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.5, 4.4 Hz, 4H, = 7.2 Hz, 3H, = 8.2 Hz, 1H, = 2.2 Hz, 1H, = 9.3, 8.4, 2.3, 1.0 Hz, 2H, = 8.8 Hz, 2H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 2.1 Hz, 1H, = 8.0, 2.3, 1.2 Hz, 1H, = 8.9, 7.1 Hz, 2H, = 8.2 Hz, 1H, = 2.3 Hz, 1H, = 5.5, 2.0, 0.9 Hz, 1H, = 8.8, 1.3 Hz, 2H, = 8.6 Hz, 2H, = 6.5 Hz, 2H, = 15.3 Hz, 3H, = 6.5 Hz, 2H, = 6.5 Hz, 3H, = 11.8 Hz, 9H, = 23.0 Hz, 2H, = 8.1 Hz, 1H, = 8.1, 2.4, 1.2 Hz, 1H, = 6.5 Hz, 2H, = 11.0 Hz, 3H, = 6.5 Hz, 2H, =.and H.W. 0.9 Hz, 2H, = 6.0 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 8.1 Hz, 1H, = 8.5, 2.5, 0.9 Hz, 1H, = 7.8, 2.0, 0.9 Hz, 1H, = 2.2 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 8.7, 7.7 Hz, 1H, = 7.9, 2.2 Hz, 2H, = 1.9 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 8.1 Hz, 1H, = 2.2 Hz, 1H, = 0.8 Hz, 3H, = 0.8 Hz, 3H, = 2.2 Hz, 1H, = 7.9, 6.8, 2.0, 0.9 Hz, 2H, = 8.0, 2.3, 1.1 Hz, 1H, = 8.1, 2.2, 1.2 Hz, 2H, = 8.5 Hz, 2H, = 8.9 Hz, 2H, = 6.0 Hz, 1H, = 8.1 Hz, 1H, = 8.4, 2.5, 0.9 Hz, 1H, = 6.0 Hz, 1H, = 6.4 Hz, 2H, = 6.4 Hz, 3H, = 6.6 Hz, 2H, = 6.4 Hz, 3H, = 12.4, 8.1 Hz, 15H, = 8.3, 2.8 Hz, 2H, = 6.3 Hz, 2H, = 9.5 Hz, 3H, = 6.5 Hz, 2H, = 6.8 Hz, 3H, = 12.1 Hz, 9H, = 8.1 Hz, 1H, = 8.4, 2.6, 0.9 Hz, 1H, = 7.2 Hz, 2H, = 6.6 Hz, 3H, = 6.6 Hz, 2H, = 10.5 Hz, 9H, = 8.1 Hz, 1H, = 8.0, 2.4, 1.2 Hz, 1H, = 6.3 Hz, 2H, = 5.4 Hz, 3H, = 6.6 Hz, 2H, = 9.5 Hz, 9H, = 8.3 Hz, 2H, = 6.4 Hz, 2H, = 6.3 Hz, 3H, = 6.5 Hz, 2H, = 7.0 Hz, 3H, = 11.3 Hz, 9H, = 9.1, 2.5 Hz, 2H, = 7.0 Hz, 2H, = 7.2 Hz, 2H, = 11.2 Hz, 9H, = 1.5 Hz, 3H, = 8.2 Hz, 1H, = 9.6 Hz, 1H, = 6.0 Hz, 1H, = 4.2 Hz, 3H, = 7.0 Hz, 2H, = 7.1 Hz, 2H, = 15.1 Hz, 9H, = 4.2 Hz, 3H, = 7.1 Hz, 2H, = 8.2 Hz, 1H, = 2.3 Hz, 1H, = 6.8, 2.8, 1.9, 0.9 Hz, 1H, = 7.1 Hz, 2H, = 7.2 Hz, 2H, = 8.0, 4.1, 2.0 Hz, 2H, = 7.3, 2.5, 1.2 Hz, 1H, = 7.1 Hz, 2H, = 7.4 Hz, 2H, = 5.5, 4.9 Hz, 1H, = 14.9, 6.8 Hz, 2H, = 4.9, 2.1 Hz, 3H, = 37.8 Hz, 3H, = 8.4, 7.4, 0.9 Hz, 1H, = 8.5, 2.3, 1.1 Hz, 1H, = 6.1 Hz, 1H, = 6.2, 1.3 Hz, 2H, = 6.4, 1.3 Hz, 2H, = 0.7 Hz, 3H, = 8.5, 2.5, 0.9 Hz, 1H, = 8.1, 1.5 Hz, 1H, = 4.2 Hz, 2H, = 3.9 Hz, 2H, = 6.4 Hz, 2H, = 6.4 Hz, 2H, = 1.2 Hz, 2H, = 6.1 Hz, 1H, = 8.1 Hz, 1H, = 8.5, 2.4, 0.9 Hz, 1H, = 8.5, 7.8 Hz, 1H, = 8.6, 2.5, 0.9 Hz, 1H, = 2.2 Hz, 1H, = 7.8, 2.1, 0.9 Hz, 1H, = 1.3 Hz, 2H, = 1.3 Hz, 3H, = 7.9, 2.0, 1.0 Hz, 1H, = 7.1 Hz, 2H, = 7.2 Hz, 3H, = 8.0 Hz, 1H, = 7.9, 2.1, 1.0 Hz, 1H, = 2.1 Hz, 1H, = 8.2, 2.4, 1.0 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.2 Hz, 2H, = 7.1 Hz, 3H, = 6.9, 2.3 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.5, 4.4 Hz, 4H, = 7.2 Hz, 3H, = 8.2 Hz, 1H, = 2.2 Hz, 1H, = 9.3, 8.4, 2.3, 1.0 Hz, 2H, = 8.8 Hz, 2H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 2.1 Hz, 1H, = 8.0, 2.3, 1.2 Hz, 1H, = 8.9, 7.1 Hz, 2H, = 8.2 Hz, 1H, = 2.3 Hz, 1H, = 5.5, 2.0, 0.9 Hz, 1H, = 8.8, 1.3 Hz, 2H, = 8.6 Hz, 2H, = 6.5 Hz, 2H, = 15.3 Hz, 3H, = 6.5 Hz, 2H, = 6.5 Hz, 3H, = 11.8 Hz, 9H, = 23.0 Hz, 2H, = 8.1 Hz, 1H, = 8.1, 2.4, 1.2 Hz, 1H, = 6.5 Hz,.analyzed the data; W.H., H.W. Hz, 1H, = 2.2 Hz, 1H, = 11.7, 8.4, 2.2, 0.9 Hz, 2H, = 6.0 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 8.1 Hz, 1H, = 8.5, 2.5, 0.9 Hz, 1H, = 7.8, 2.0, 0.9 Hz, 1H, = 2.2 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 8.7, 7.7 Hz, 1H, = 7.9, 2.2 Hz, 2H, = 1.9 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 8.1 Hz, 1H, = 2.2 Hz, 1H, = 0.8 Hz, 3H, = 0.8 Hz, 3H, = 2.2 Hz, 1H, = 7.9, 6.8, 2.0, 0.9 Hz, 2H, = 8.0, 2.3, 1.1 Hz, 1H, = 8.1, 2.2, 1.2 Hz, 2H, = 8.5 Hz, 2H, = 8.9 Hz, 2H, = 6.0 Hz, 1H, = 8.1 Hz, 1H, RAC1 = 8.4, 2.5, 0.9 Hz, 1H, = 6.0 Hz, 1H, = 6.4 Hz, 2H, = 6.4 Hz, 3H, = 6.6 Hz, 2H, = 6.4 Hz, 3H, = 12.4, 8.1 Hz, 15H, = 8.3, 2.8 Hz, 2H, = 6.3 Hz, 2H, = 9.5 Hz, 3H, = 6.5 Hz, 2H, = 6.8 Hz, 3H, = 12.1 Hz, 9H, = 8.1 Hz, 1H, = 8.4, 2.6, 0.9 Hz, 1H, = 7.2 Hz, 2H, = 6.6 Hz, 3H, = 6.6 Hz, 2H, = 10.5 Hz, 9H, = 8.1 Hz, 1H, = 8.0, 2.4, 1.2 Hz, 1H, = 6.3 Hz, 2H, = 5.4 Hz, 3H, = 6.6 Hz, 2H, = 9.5 Hz, 9H, = 8.3 Hz, 2H, = 6.4 Hz, 2H, = 6.3 Hz, 3H, = 6.5 Hz, 2H, = 7.0 Hz, 3H, = 11.3 Hz, 9H, = 9.1, 2.5 Hz, 2H, = 7.0 Hz, 2H, = 7.2 Hz, 2H, = 11.2 Hz, 9H, = 1.5 Hz, 3H, = 8.2 Hz, 1H, = 9.6 Hz, 1H, = 6.0 Hz, 1H, = 4.2 Hz, 3H, = 7.0 Hz, 2H, = 7.1 Hz, 2H, = 15.1 Hz, 9H, = 4.2 Hz, 3H, = 7.1 Hz, 2H, = 8.2 Hz, 1H, = 2.3 Hz, 1H, = 6.8, 2.8, 1.9, 0.9 Hz, 1H, = 7.1 Hz, 2H, = 7.2 Hz, 2H, = 8.0, 4.1, 2.0 Hz, 2H, = 7.3, 2.5, 1.2 Hz, 1H, = 7.1 Hz, 2H, = 7.4 Hz, 2H, = 5.5, 4.9 Hz, 1H, = 14.9, 6.8 Hz, 2H, = 4.9, 2.1 Hz, 3H, = 37.8 Hz, 3H, = 8.4, 7.4, 0.9 Hz, 1H, = 8.5, 2.3, 1.1 Hz, 1H, = 6.1 Hz, 1H, = 6.2, 1.3 Hz, 2H, = 6.4, 1.3 Hz, 2H, = 0.7 Hz, 3H, = 8.5, 2.5, 0.9 Hz, 1H, = 8.1, 1.5 Hz, 1H, = 4.2 Hz, 2H, = 3.9 Hz, 2H, = 6.4 Hz, 2H, = 6.4 Hz, 2H, = 1.2 Hz, 2H, = 6.1 Hz, 1H, = 8.1 Hz, 1H, = 8.5, 2.4, 0.9 Hz, 1H, = 8.5, 7.8 Hz, 1H, = 8.6, 2.5, 0.9 Hz, 1H, = 2.2 Hz, 1H, = 7.8, 2.1, 0.9 Hz, 1H, = 1.3 Hz, 2H, = 1.3 Hz, 3H, = 7.9, 2.0, 1.0 Hz, 1H, = 7.1 Hz, 2H, = 7.2 Hz, 3H, = 8.0 Hz, 1H, = 7.9, 2.1, 1.0 Hz, 1H, = 2.1 Hz, 1H, = 8.2, 2.4, 1.0 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.2 Hz, 2H, = 7.1 Hz, 3H, = 6.9, 2.3 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.5, 4.4 Hz, 4H, = 7.2 Hz, 3H, = 8.2 Hz, 1H, = 2.2 Hz, 1H, = 9.3, 8.4, 2.3, 1.0 Hz, 2H, = 8.8 Hz, 2H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 2.1 Hz, 1H, = 8.0, 2.3, 1.2 Hz, 1H, = 8.9, 7.1 Hz, 2H, = 8.2 Hz, 1H, = 2.3 Hz, 1H, = 5.5, 2.0, 0.9 Hz, 1H, = 8.8, 1.3 Hz, 2H, = 8.6 Hz, 2H, = 6.5 Hz, 2H, = 15.3 Hz, 3H, = 6.5 Hz, 2H, = 6.5 Hz, 3H, = 11.8 Hz, 9H, = 23.0 Hz, 2H, = 8.1 Hz, 1H, = 8.1, 2.4, 1.2 Hz, 1H, = 6.5 Hz, 2H, = 11.0 Hz, 3H, = 6.5 Hz, 2H, = 4.4 Hz, 3H, = 8.5 Hz, 9H, = 8.8 Hz, 2H, = 6.5 Hz, 2H,.Among them, five chemical substances (9a, 9f, 16c, 18a, 18e) showed strong inhibitory effects on PRMT1. Hz, 2H, = 7.1 Hz, 3H, = 6.1 Hz, 1H, = 7.1 Hz, 2H, = 7.9, 6.6 Hz, 9H, = 8.1 Hz, 1H, = 2.2 Hz, 1H, = 11.7, 8.4, 2.2, 0.9 Hz, 2H, = 6.0 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 8.1 Hz, 1H, = 8.5, 2.5, 0.9 Hz, 1H, = 7.8, 2.0, 0.9 Hz, 1H, = 2.2 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 8.7, 7.7 Hz, 1H, = 7.9, 2.2 Hz, 2H, = 1.9 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 8.1 Hz, 1H, = 2.2 PF-04957325 Hz, 1H, = 0.8 Hz, 3H, = 0.8 Hz, 3H, = 2.2 Hz, 1H, = 7.9, 6.8, 2.0, 0.9 Hz, 2H, = 8.0, 2.3, 1.1 Hz, 1H, = 8.1, 2.2, 1.2 Hz, 2H, = 8.5 Hz, 2H, = 8.9 Hz, 2H, = 6.0 Hz, 1H, = 8.1 Hz, 1H, = 8.4, 2.5, 0.9 Hz, 1H, = 6.0 Hz, 1H, = 6.4 Hz, 2H, = 6.4 Hz, 3H, = 6.6 Hz, 2H, = 6.4 Hz, 3H, = 12.4, 8.1 Hz, 15H, = 8.3, 2.8 Hz, 2H, = 6.3 Hz, 2H, = 9.5 Hz, 3H, = 6.5 Hz, 2H, = 6.8 Hz, 3H, = 12.1 Hz, 9H, = 8.1 Hz, 1H, = 8.4, 2.6, 0.9 Hz, 1H, = 7.2 Hz, 2H, = 6.6 Hz, 3H, = 6.6 Hz, 2H, = 10.5 Hz, 9H, = 8.1 Hz, 1H, = 8.0, 2.4, 1.2 Hz, 1H, = 6.3 Hz, 2H, = 5.4 Hz, 3H, = 6.6 Hz, 2H, = 9.5 Hz, 9H, = 8.3 Hz, 2H, = 6.4 Hz, 2H, = 6.3 Hz, 3H, = 6.5 Hz, 2H, = 7.0 Hz, 3H, = 11.3 Hz, 9H, = 9.1, 2.5 Hz, 2H, = 7.0 Hz, 2H, = 7.2 Hz, 2H, = 11.2 Hz, 9H, = 1.5 Hz, 3H, = 8.2 Hz, 1H, = 9.6 Hz, 1H, = 6.0 Hz, 1H, = 4.2 Hz, 3H, = 7.0 Hz, 2H, = 7.1 Hz, 2H, = 15.1 Hz, 9H, = 4.2 Hz, 3H, = 7.1 Hz, 2H, = 8.2 Hz, 1H, = 2.3 Hz, 1H, = 6.8, 2.8, 1.9, 0.9 Hz, 1H, = 7.1 Hz, 2H, = 7.2 Hz, 2H, = 8.0, 4.1, 2.0 Hz, 2H, = 7.3, 2.5, 1.2 Hz, 1H, = 7.1 Hz, 2H, = 7.4 Hz, 2H, = 5.5, 4.9 Hz, 1H, = 14.9, 6.8 Hz, 2H, = 4.9, 2.1 Hz, 3H, = 37.8 Hz, 3H, = 8.4, 7.4, 0.9 Hz, 1H, = 8.5, 2.3, 1.1 Hz, 1H, = 6.1 Hz, 1H, = 6.2, 1.3 Hz, 2H, = 6.4, 1.3 Hz, 2H, = 0.7 Hz, 3H, = 8.5, 2.5, 0.9 Hz, 1H, = 8.1, 1.5 Hz, 1H, = 4.2 Hz, 2H, = 3.9 Hz, 2H, = 6.4 Hz, 2H, = 6.4 Hz, 2H, = 1.2 Hz, 2H, = 6.1 Hz, 1H, = 8.1 Hz, 1H, = 8.5, 2.4, 0.9 Hz, 1H, = 8.5, 7.8 Hz, 1H, = 8.6, 2.5, 0.9 Hz, 1H, = 2.2 Hz, 1H, = 7.8, 2.1, 0.9 Hz, 1H, = 1.3 Hz, 2H, = 1.3 Hz, 3H, = 7.9, 2.0, 1.0 Hz, 1H, = 7.1 Hz, 2H, = 7.2 Hz, 3H, = 8.0 Hz, 1H, = 7.9, 2.1, 1.0 Hz, 1H, = 2.1 Hz, 1H, = 8.2, 2.4, 1.0 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.2 Hz, 2H, = 7.1 Hz, 3H, = 6.9, 2.3 Hz, 1H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 7.5, 4.4 Hz, 4H, = 7.2 Hz, 3H, = 8.2 Hz, 1H, = 2.2 Hz, 1H, = 9.3, 8.4, 2.3, 1.0 Hz, 2H, = 8.8 Hz, 2H, = 7.1 Hz, 2H, = 7.1 Hz, 3H, = 2.1 Hz, 1H, = 8.0, 2.3, 1.2 Hz, 1H, = 8.9, 7.1 Hz, 2H, = 8.2 Hz, 1H, = 2.3 Hz, 1H, = 5.5, 2.0, 0.9 Hz, 1H, = 8.8, 1.3 Hz, 2H, = 8.6 Hz, 2H, = 6.5 Hz, 2H, = 15.3 Hz, 3H, = 6.5 Hz, 2H, = 6.5 Hz, 3H, = 11.8 Hz, 9H, = 23.0 Hz, 2H, = 8.1 Hz,.